|
KMID : 0390220210320010005
|
|
Journal of Clinical Otolaryngology, Head and Neck Surgery
2021 Volume.32 No. 1 p.5 ~ p.19
|
|
|
Diagnosis and Intervention of Genetic Hearing Loss
|
|
Na Gi-Na
Jung Jin-Sei
|
|
|
Abstract
|
|
|
|
Sensorineural hearing loss (SNHL) is the most common sensory disorder in humans. A wide range of genetic and environmental factors that can cause congenital or late-onset, stable or progressive, age-related, drug-related, noise-causing, post-infection, or traumatic hearing loss leads to the SNHL. More and more comprehensive genetic studies have recently been published in patients with hearing loss in the era of target genome and massively parallel sequencing. Although rehabilitation options, to date, typically have focused on amplification with wearables or implantable devices, intriguing new gene therapy-based strategies to restore and prevent SNHL are actively being investigated using an animal model. Correcting or preventing an underlying genetic cause of hearing loss is ready to become a reality. In this article, several methods for diagnosis and treatment strategies for hereditary hearing loss in progress to date are introduced.
|
|
|
KEYWORD
|
|
|
Genetic hearing loss, Next generation sequencing, Precision medicine, Gene therapy, Gene editing
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|